请选择 进入手机版 | 继续访问电脑版

问题 14. 与白癜风倾向相关 的个人因素有哪些?

2019-3-1 13:03| 发布者: admin| 查看: 689| 评论: 0

摘要: 问题 14. 与白癜风倾向相关 的个人因素有哪些?

Question 14. What are the individual factors associated with propensity to vitiligo?

 

问题 14. 与白癜风倾向相关 的个人因素有哪些?

Key points

要点

Heridity: 20% of people with vitiligo report about a first degree relative as the one suffering from vitiligo.

 

20%患者的一患白癜风

 

Human  Leukocyte  Antigen  (HLA) haplotype may contribute to vitiligo susceptibility.

 

人类白细胞抗原(HLA)单倍型可能导致白 癜风易感性

 

A number of pathological conditions have been associated with vitiligo: their presence might be considered a propensity to disease development.

 

 

许多病理状态与白癜风相关:其被认为可 能是疾病发展的诱因

The  disease  onset  is  frequently  associated with stressful life events.

 

白癜风发病多与应激性生活事件有关

Physical  trauma  of  the      skin  may  induce vitiligo (Koebner phenomenon).

 

起白应)


 

Answer

解答

It is well-known that heredity is an issue in vitiligo propensity. In fact, around 20% of people with vitiligo report about a first degree relative as the one suffering from the same disorder. Children of a vitiligo affected subject have a 1.7-fold increased risk of developing vitiligo compared with other family members. HLA haplotypes may contribute to generalized  vitiligo  susceptibility,  i.e.  HLAs

-A2, -DR4, - DR7 and -DQB1 0303.

 

众所周知,遗传是白癜风的一个易患因素。 20%的白癜风患者称他们一级亲属中有人 患有患者的子患 病风 1.7 类白细胞抗原单倍型可能增加泛发型白癜 风的易感性,如 HLAs-A2-DR4-DR7and

-DQB1 0303

 

NALP-1 gene (NACHT leucine rich- repeat protein 1) is a major susceptibility gene that is epidemiologically linked to generalized vitiligo and other autoimmune diseases (i.e. thyroid disease, pernicious anemia, and lupus erythematosus).

 

NALP-1 NACHT 富亮氨酸 1), 从流来说是与泛发其 他自状腺血和 红斑狼疮)相关的主要易感基因。

 

Patients already affected by the following diseases are more prone to develop vitiligo (and vice versa):

 

患下发展(反 之亦

Alopecia    areata    Pernicious    anemia    IgA selective defect

 

斑秃、恶性贫血、IgA 选择性缺陷

Thyroid autoimmune disease

自身免疫性甲状腺疾病

Addison’s disease

Addison 病。

Congenital melanocytic neviMELAS syndrome (mitochondrial encephalomyopathy, lactic acidosis, and stroke episodes syndrome).

 

先天 neviMELAS 线粒 体脑肌病、乳酸中毒、中风发作综合征)

Stressful life events, probably interfering with the psycho-neuro-endocrine-immune system, and physical traumas of skin, including solar burns, may easily promote vitiligo onset in predisposed subjects.

应激性生活事件可能干扰心理-神经-内分 -免疫系统;另外皮肤物理性损伤,包括 日光灼伤发易感染癜 风。


鲜花

握手

雷人

路过

鸡蛋
该文章已有0人参与评论

请发表评论

全部评论

推荐帖子
发几张恢复的照片
这是已经服用中医治疗4个月到1年3个月的对比。目前已经不间断用药一年半。
广告:白白之家最新活动推荐
白白之家最新活动推荐:与UVA厂家合作优惠活动如下:UVA厂家与白白之家论坛合作,UVA
放松心态!
第一张图,照灯半个月。白斑处开始变红,没任何感觉。第二张图,3个月左右吧!我想说
蔡老给了我希望
2016年7月底,照镜子发现自己眉毛有几根白色,总是感觉不对劲,然后去了我们当地的二
我女儿治疗的两个月,效果好不错

微信二维码

扫一扫加微信

Powered by Discuz! X3.4© 2001-2013 Comsenz Inc.( 冀ICP备2022030148号 )