白白之家 › 首页 ›紫外线光疗仪-旭达黑光灯› 白癜风论坛文章 › 查看内容

问题 14. 与白癜风倾向相关的个人因素有哪些？

2019-3-1 13:03| 发布者: admin| 查看: 708| 评论: 0

摘要: 问题 14. 与白癜风倾向相关的个人因素有哪些？

Question 14. What are the individual factors associated with propensity to vitiligo?

•Key points

•要点

•Heridity: 20% of people with vitiligo report about a first degree relative as the one suffering from vitiligo.

•遗传：20%的白癜风患者的一级亲属中有人患白癜风

Human Leukocyte Antigen (HLA) haplotype may contribute to vitiligo susceptibility.

•人类白细胞抗原(HLA)单倍型可能导致白癜风易感性

•A number of pathological conditions have been associated with vitiligo: their presence might be considered a propensity to disease development.

•许多病理状态与白癜风相关：其被认为可能是疾病发展的诱因

•The disease onset is frequently associated with stressful life events.

•白癜风发病多与应激性生活事件有关

•Physical trauma of the skin may induce vitiligo (Koebner phenomenon).

•皮肤的物理创伤可引起白癜风（同形反应）

Answer	解答
It is well-known that heredity is an issue in vitiligo propensity. In fact, around 20% of people with vitiligo report about a first degree relative as the one suffering from the same disorder. Children of a vitiligo affected subject have a 1.7-fold increased risk of developing vitiligo compared with other family members. HLA haplotypes may contribute to generalized vitiligo susceptibility, i.e. HLAs -A2, -DR4, - DR7 and -DQB1 0303.	众所周知，遗传是白癜风的一个易患因素。约 20%的白癜风患者称他们一级亲属中有人患有白癜风。白癜风患者的子女的白癜风患病风险比其他家庭的子女增加了 1.7 倍。人类白细胞抗原单倍型可能增加泛发型白癜风的易感性，如 HLAs-A2，-DR4，-DR7and -DQB1 0303。
NALP-1 gene (NACHT leucine rich- repeat protein 1) is a major susceptibility gene that is epidemiologically linked to generalized vitiligo and other autoimmune diseases (i.e. thyroid disease, pernicious anemia, and lupus erythematosus).	NALP-1 基因（NACHT 富亮氨酸重复蛋白 1），从流行病学上来说，是与泛发型白癜风及其他自身免疫病（如甲状腺疾病、恶性贫血和红斑狼疮）相关的主要易感基因。
Patients already affected by the following diseases are more prone to develop vitiligo (and vice versa):	患下列疾病的患者更容易发展成白癜风（反之亦然）：
Alopecia areata Pernicious anemia IgA selective defect	斑秃、恶性贫血、IgA 选择性缺陷
Thyroid autoimmune disease	自身免疫性甲状腺疾病
Addison’s disease	Addison 病。
Congenital melanocytic neviMELAS syndrome (mitochondrial encephalomyopathy, lactic acidosis, and stroke episodes syndrome).	先天性黑素细胞的 neviMELAS 综合征（线粒体脑肌病、乳酸中毒、中风发作综合征）
Stressful life events, probably interfering with the psycho-neuro-endocrine-immune system, and physical traumas of skin, including solar burns, may easily promote vitiligo onset in predisposed subjects.	应激性生活事件可能干扰心理-神经-内分泌-免疫系统；另外皮肤物理性损伤，包括日光灼伤，很容易诱发易感染人群发生白癜风。